One doesn't need a flat trajectory, one needs to just know the arc. With at most 566ftlbs of energy at 1000fps, and the very soft lead bullets of the day I doubt the. 45Colt loaded with the 255gr slug, and 35-40grs of blackpowder would barely push break 1000fps in longer pistols. The great slaughter was committed with mostly the 50-70 and it's child cartridges, and the 45-70 and it's child cartridges - very different cartridges from the. Bison weren't timid of humans if you didn't act like a hooligan. NymanRarely, and probably at close range if they did. 45 Colt, sure it can, just use a hot enough load to give you that flatter trajectory that you need. The 270-SAA is easy to shoot and at 1000fps, both accurate and impressive terminally.In the old days people used to hunt Buffalo with the. That having been said, I find that there really isn't an awful lot of need to do that any longer. However, if I want to push things a little more, say with a 300grJHP, AA#9 is there. Accuracy and consistency is excellent, easy to do with AA#9. It takes care of most things that need taken care of. I'm perfectly happy pushing a 282gr RCBS45-270-SAA at 1000fps. WW296/H110 are a little more limited in that capacity. But it doesn't necessarily need to be an all out there powder either, especially if you want heavy loads as well as "moderately heavy" loads. You can't turn it into a standard pressure powder with light bullets, that's for sure. Since the OPs criteria of one powder specified "heavy bullets and powerful loads" (which I must assume to mean starting somewhere at RCBS45-270-SAA and up and higher tier pressures over 22Kpsi), AA#9 is a decent performer. But most of those don't easily fit the Heavy and Hot criteria either.
There are many and better powder options to use for standard weight bullets and pressures. I agree with you if you are using bullets in that weight range and standard pressure loads, or perhaps even those approaching 20-22Kpsi range.
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